王金辉 导师简介

发布者:教科办发布时间:2019-01-22浏览次数:2885

一、基本信息

王金辉,药物化学博士,哈尔滨医科大学二级教授,博士生导师,先后入选教育部“新世纪优秀人才支持计划”、“辽宁省百人计划”等。主要致力于中药和天然药物中药效成分的研究与开发、中药有效成分代谢和动力学研究、中药炮制及饮片质量规范化研究、中药创新药物的研究与开发、基于基因组学、代谢组学的中药复方配伍机制研究;作为首席科学家主持国家科技支撑计划项目1项、国家科技重大专项重大新药创制、国家863课题1项,国家自然科学基金等项目;获得发明专利10多项;2006年以来,SCI收录论文100余篇, EI收录论文8篇专著4部;获新疆生产建设兵团科技进步一等奖1项、辽宁省科技进步二等奖2项、新疆生产建设兵团科技进步二等奖2项、新疆自治区科技进步二等奖1项,获新疆生产建设兵团青年科技奖、辽宁省青年科技奖。

二、学术经历(从近到远……)

1.  2017/3-哈尔滨医科大学威尼人登录网址教授

2. 2003-沈阳药科大学中威尼人登录网址教授

3. 2000-沈阳药科大学中威尼人登录网址副教授

4. 1999-沈阳药科大学中威尼人登录网址讲师

三、教育经历(从近到远……)

1.  1999-沈阳药科大学药物化学博士学位

2.  1994阳药科大学威尼人登录网址药学学士学位

四、曾获奖励(从近到远……)可以分类:科技进步奖励、优秀论文……

1.  14种天然药物中抗肿瘤活性成分作用机制及其应用研究, 中国医药教育协会科学技术进步奖,二等奖,2016,No.2016KC-G2-6-06

2. 治疗肝病的菊苣等新疆特色中药民族药物质基础研究和开发应用,新疆维吾尔自治区科学技术进步奖,二等奖,2016No.G20150511

3.新疆11种中药、民族药化学成分分离、分析方法及生物活性研究,新疆生产建设兵团科技进步,一等奖,2013,No.201310309

4.  新疆阿魏菇多糖对宫颈癌U14荷瘤鼠抗癌作用及免疫调节机制的研究,新疆生产建设兵团科技进步,二等奖,2012No.201222202

5.  新疆红花GAP种植关键技术研究与应用,新疆生产建设兵团科技进步,二等奖,2012No. 201222203

6.  肉豆蔻等10 种中药饮片炮制工艺及质量标准规范化研究,辽宁省科学技术奖励,二等奖,2007No.2007J-70-07

五、曾获荣誉(从近到远……)

1.  2005 入选教育部新世纪优秀人才支持计划

2.  2004 辽宁省百千万人才工程百人层次人选

  

六、主持科学研究项目(从近到远……)

1.  国家科技重大专项重大新药创制《中药民族药组分资源库建设》(2018ZX09735-005),2018.01-2020.121406.88万元。

2.  国家中药标准化项目《护肝片标准化研究》(ZYBZH-C-HLJ-15),2016.01-2018.12500万元。

3.  国家中药标准化项目《山药等两种饮片标准化研究》ZYBZH-Y-HEB-162016.01-2018.12600万元。

4.  国家自然科学基金地区基金《圆根大戟和甘遂中保护多巴胺所致SH-SY5Y 细胞损伤帕金森模型作用和机制研究》(81260628),2013.01-2016.1249万元。

5.  国家自然科学基金《新疆特有药材鹿草中蜕皮甾酮类成分保护兴奋性氨基酸Glu所致神经损伤作用机制及其构效关系研究》(U1303124),2014.01-2016.1260万元。

6. 国家自然科学基金新疆联合基金《新疆荒漠植物多伞阿魏中彗星状化合物对神经胶质瘤C6细胞的抗肿瘤作用及其机制研究》(U1170302),2012.01-2015.1250万元。

7. 国家科技支撑计划项目,2012BAI30B02,《维药现代化开发关键技术研究与示范》,2012.01-2015.12999万元。

8. 国家自然科学基金地区基金《新疆鼠尾草属植物改善心肌缺血有效成分-丹参酚酸A及其构效关系研究》(20762008),2008.01-2010.1225万元。

9. 国家863课题《阿魏侧耳免疫调节多糖制备技术及其口含给药系统的研究》(2008AA10Z323),2008/03-2010/10,48万元。

七、主持教学研究项目(从近到远……)

八、讲授课程

1.  硕士研究生:波普解析

2.  本科生课程:天然药物化学、波普解析、药学英语、药学概论

  

九、代表性成果(从近到远……)

1.  代表论文

[1]Li Xiao-Xiao, Zhang Shi-Jie, Chiu Amy P., Lo Lilian H., Huang Jian, Rowlands Dewi K., Wang Jinhui*, Keng Vincent W*. Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor. Cancer Medicine, 2018, 7: 4791-4800

[2]Yiting Wang, Yanmei Chen, Xiaoling Cheng, Ke Zhang, Hangyu Wang*, Bo Liu*, Jinhui Wang*.,Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells. Bioorganic & Medicinal Chemistry, 2018, 26: 3491-3501

[3]Xiaobo Pang, Ke Zhang, Jian Huang, Hangyu Wang, Le Gao, Tao Wang, Yingnan Sun, Long Chen, Jinhui Wang*. Decryption of Active Constituents and Action Mechanism of the Traditional Uighur Prescription (BXXTR) Alleviating IMQ-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice. International Journal of Molecular Sciences, 2018, 19: 1822-1839

[4]JinLu, LeiShang, HuiminWen, JianHuang*, GuoyuLi, JinhuiWang*. Structural identification and biological activity of six new Shellolic esters from Lac. Fitoterapia, 2018, 125: 221-226

[5]Jiming Wu, Le Gao, Lei Shang, Guihua Wang, Nana Wei, Tiantian Chu, Suping Chen,Yujun Zhang, Jian Huang*, Jinhui Wang*, Ruichao Lin*. Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats. Fitoterapia. 2017 , 119:158-167

[6]Jin Zhang, Dahong Yao, Yingnan Jiang, Jian Huang, Shilin Yang*, Jinhui Wang*. Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells. Bioorganic Chemistry. 2017, 72:168-181.

[7]Wang Zhen-Hui, Huang Jian, Niu Chao, Wang Jin-Hui*, Wu Bin*. Isopimarane-type diterpenoids from Callicarpa macrophylla vahl. Phytochemistry, 2017, 22: 224-228

[8]Yao Dahong, Wang Jing, Wang Guan, Jiang Yingnan, Shang Lei, Zhao Yuqian, Huang, Jian, Yang Shilin*, Wang Jinhui*, Yu Yamei*. Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells. Bioorg Chem. 2016, 68:112-123

[9]Yingnan Jiang, Ke Zhang, Guihua Wang, Jian Huang, Jinhui Wang*, Lixia Chen*. Discovery of potent c-MET inhibitors with inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups. Molecules. 2016, 21: 612-627.

[10] Jin Zhang, Xiangdong Jiang, Yingnan Jiang, Mingrui Guo, Shouyue Zhang, Jingjing Li, Jun He, Jie Liu, Jinhui Wang*, Liang Ouyang*. Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs. European Journal of Medicinal Chemistry. 2016, 108: 495-504.

[11] Shuyun Wang, Honggang Liang, Yuqian Zhao, Guihua Wang, Hong Yao, Rena Kasimu, Zhaohua Wu, Yan Li, Jian Huang*, Jinhui Wang*. New triterpenoids from the latex of Euphorbia resinifera Berg. Fitoterapia. 2016,  108: 33-40

[12] Jiming Wu, Jinghan Li, Jin Zhang, Xinyue Hu, Dahong Yao, Liang Ma, Liang Ouyang, Xinhui Pan, Jian Huang*, Ruichao Lin*, Jinhui Wang. In silico identification and experimental validation of diuresis compounds from Euphorbia lathyris for potential UT-B inhibitors. Journal of the Taiwan Institute of Chemical Engineers. 2016, 60: 124-137

[13] Ke Zhang, Xiao-ping Si, Jian Huang*, Jian Han, Xu Liang, Xiaobo Xu, Guo-yu Li, Yi-ting Wang, Hang-yu Wang, Jin-hui Wang*. Preventive effects of Rhodiola rosea L. on bleomycin-induced pulmonary fibrosis in rats. International journal of Molecular Sciences. 2016, 17: 879-900

[14] Lan Zhang, Xupeng Tong, Jin Zhang, Jian Huang*, Jinhui Wang*. DAW22, a natural sesquiterpene coumarin isolated from Ferula ferulaeoides (Steud.) Korov. that induces C6 glioma cell apoptosis and endoplasmic reticulum (ER) stress. Fitoterapia. 2015, 103: 46-54

[15]  Huang Jian, Zheng Yaxin, Wu Wenxi, Xie Tao, Yao Hong, Pang Xiaobo, Sun Fuzhou, Ouyang Liang, Wang Jinhui*. CEMTDD: The database for elucidating the relationships among herbs, compounds, targets and related diseases for Chinese ethnic minority traditional drugs. Oncotarget. 2015, 6: 17675-17684

[16] Lan Zhang, Xupeng Tong, Jingjing Li, Yue Huang, Xinyue Hu, Yi Chen, Jian Huang, Jinhui Wang*, Bo Liu*. Apoptotic and autophagic pathways with relevant small-molecule compounds, in cancer stem cells. Cell Proliferation. 2015, 48(4): 385-397

[17] Jin Zhang, Lei-lei Fu, Mao Tian, Hao-qiu Liu, Jingjing Li, Yan Li, Jun He, Jian Huang*, Liang Ouyang*, Hui-yuan Gao, Jin-hui Wang*. Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy. Bioorgan Med Chem. 2015, 23: 976-984

[18] Gao HY, Li GY, Wang H Y, Huang J, Du XW, Han Y, Wang LF, Wang JH*. Constituents from Zhuyeqing Liquor with hepatoprotective effect on alcohol-induced HepaG 2 toxicity. Archives of pharmacal research. 2015, 38(5): 683-690

[19] Jian Huang, Jin-hui Wang*. CEMTDD: Chinese Ethnic Minority Traditional Drug Database. Apoptosis. 2014, 19(9): 1419-1420

[20] Shuyun Wang, Jian Huang*, Huijuan Mao, Yuliang Wang, Rena Kasimu, Wei Xiao, Jinhui Wang*. A Novel Method HPLC-DAD Analysis of the Contentsof Moutan Cortexand Paeoniae Radix Alba with Similar Constituents-Monoterpene Glycosides in Guizhi Fuling Wan. Molecules. 2014, 19(11): 17957-17967.

[21] Yun Zhu, Chang-hua Xu, Jian Huang, Guo-yu Li, Qun Zhou, Xin-Hu Liu, Su-qin Sun*, Jin-hui Wang*. Rapid discrimination of three Uighur medicine of Eremurus by FT-IR combined with 2DCOS-IR. Journal of Molecular Structure. 2014, 1069: 96-102

[22] He Meng, Guoyu Li, Jian Huang, Ke Zhang, Xiuyan Wei, Yueping Ma, Cui Zhang, Jinhui Wang*. Sesquiterpenoid derivatives from Ferula ferulaeoides (Steud.) Korov. Phytochemistry. 2013, 86 :151-158.

[23] Gao HY, Li GY, Huang J, Han Y, Sun FZ, Du XW, An LJ, Wang HY*, Wang JH*. Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo. BMC complementary and alternative medicine. 2013, 13: 252-258

[24] Xin-Hu Liu, Huan-Jun Xu, Su-Qin Sun, Jian Huang, Guo-Yu Li, Yun Zhu, Hong-Ying Gao, Zhi-Cheng Zhang, Jin-Hui Wang*. Analysis and identification of Chinese drugs by three-step infrared spectroscopy-A case study of Danshen. Analytical Methods. 2012, 1039-1049

[25] Shen S, Li GY, Huang J, Tan Y, Chen CJ, Ren B, Lu G, Zhang C, Li X, Wang JH*. Chemical constituents from Fritillaria pallidiflora Schrenk. Biochem Syst Ecol. 2012, 45:183-187

2.  发明专利

[1] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314424.X, 2018-06-05

 [2]王金辉,热娜·卡斯木,李国玉,黄健,姚大红,胡君萍,马庆东,张珂,陈雪珊.多刺绿绒蒿α-糖苷酶抑制活性提取物及其组合物的医药用途和制备方法[P]. 中国:ZL201510058737, 2018-04-20

 [3] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510312850.X, 2017-12-19

[4] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510312849.7, 2017-12-19

 [5] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314168.4, 2017-10-31

[6] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314135.X, 2017-10-31

[7] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314425.4, 2017-10-24

[8] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分及其医药用途[P]. 中国:ZL201510314170.1, 2017-03-22

[9] 王金辉,李国玉,黄健,高红英,杜小威,韩英,王书云,安丽娟,王立飞,程锁明,孙富周.竹叶青酒中的生物活性成分和医药用途[P]. 中国:ZL 201310501283.3, 2015-08-12.

[10] 王金辉,曾毅梅,李国玉.一组中药芫花二萜原酸酯类化合物[P]. 中国:ZL 200910176448.8, 2012-01-25

[11] 王金辉,李国玉,巩平,魏秀岩,黄健,王莹,杨琳,卢丽娜,秦颖,张萃,阿魏侧耳多糖及其组合物的医药用途和制备方法[P]. 中国:ZL201010272986.X, 2010-09-06.

3.  代表著作

[1]《Horizons in Cancer Research》(ISBN 978-7-5429-2577),Nova Science Publishers, Inc20149月, 主编/副主编/编委。

[2]《实用天然有机产物化学》ISBN 9787117084031),人民卫生出版社,20074月,编委。

  

十、学术兼职

1.  中国中医药信息研究会食疗分会副会长

2.  中华中医药学会中药化学分会常务委员

3.  中华中医药学会中药炮制分会常务委员

4.  中国生物技术协会生物制药分会常务委员

5.  世界中医药联合会气血专业委员会常务委员

6.  新疆植物药资源利用教育部重点实验室学术委员会委员

7. 《中国现代中药》编委

  

十一、行政管理经验

1.  2002.10–2011.10 沈阳药科大学工会副主席

2.  2004.10-2006.06 沈阳药科大学中威尼人登录网址院长

十二、联系方式

1.  E-mail:15999290001@163.com

2.  通讯地址:新疆维吾尔自治区石河子市,北2路59号,石河子大学医学校区,威尼人登录网址

3. 邮编:832002

十三、学生及实验室照